The Noble journey part I

Biology, Physics, Chemistry. 23/09/10

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This is first part of the conversation with Randy Schekman. He is an investigator of the Howard Hughes Medical Institute and a Professor of Cell and Developmental Biology in the Department of Molecular and Cell Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his role in revealing the machinery that regulates the transport and secretion of proteins in our cells. He shares the prize with James E. Rothman of Yale University and Thomas C. Südhof of Stanford University.


About the guest

  • 00:00:00 Introduction

  • 00:01:08 Interest in microbes

  • 00:05:27 Yeasts have feelings too!

  • 00:06:24 What was already known about vesicular trafficking?

  • 00:08:42 How do you envision a cell?

  • 00:09:51 Your work to understand 'what is life'?

  • 00:12:48 Formation of membranes for the origin of life

  • 00:14:39 Why membranes are ideal for life!

  • 00:15:48 Differences of membranes

  • 00:17:07 The evolution of membranes

  • 00:19:02 Starting the work on vesicular trafficking

  • 00:23:09 Discovery of COPII complex

  • 00:25:24 The specialty of COPII complex

  • 00:26:30 Importance of vesicular trafficking for animal physiology

  • 00:27:39 Understanding of gut feeling!

  • 00:28:56 What has changed after Nobel prize?

  • 00:30:30 Different cellular trafficking system

  • 00:32:11 Exosomes and miR223

  • 00:34:29 Problems with exosomes as therapeutics

  • 00:35:08 Peer-review and scientific publishing

  • 00:39:44 Genesis of Elife

  • 00:44:05 Impact factor of Elife

  • 00:46:35 Thank you!

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