Understanding metabolism and aging
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This episode is with Charles Brenner. He is the Alfred E Mann Family Foundation Chair in the department of Diabetes and Cancer Metabolism. His research focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress.
Here we talk about what is metabolism?, NAD system, factors affecting NAD system, ageing, anti-ageing research and how NAD system can be used in health?
About the guest
00:00:00 Introduction
00:00:51 What is metabolism?
00:01:40 Metabolism at cellular level
00:02:44 Different metabolic processes
00:04:50 NAD (Nicotinamide adenine diamide) system
00:08:20 Food to NAD system
00:13:09 Evolutionary history of NAD system
00:15:44 Molecular description of NAD system
00:20:51 Synthesis of NAD
00:23:21 What is metabolic stress?
00:28:23 Consequences of metabolic stress on NAD system
00:29:45 Conditions caused by NAD deficiency
00:34:23 Impact of food on metabolic stress
00:35:51 Different types of foods and NAD levels
00:40:01 NAD levels and circadian rythem
00:40:50 Genetic predisposition to NAD levels
00:42:40 Are there population wide changes in NAD systems?
00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell?
00:50:08 Are there modified NMN compounds which can enter in the cell?
00:52:01 NAD system and aging
01:02:25 Objection against 'Sirtuins as drivers of aging'
01:04:29 How do we understand aging?
01:08:25 Biochemical explanation of aging
01:12:20 What kind of biomarkers can help is in studying aging?
01:15:33 Charles' work on NAD system
01:17:05 What sort of system can help us study aging?
01:23:37 Lifestyle and NAD system
01:26:07 NR (Nicotinamide Ribose) as supplements
01:27:19 Thank you!