Understanding metabolism and aging

Biology, Physics, Chemistry. 23/09/10

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This episode is with Charles Brenner. He is the Alfred E Mann Family Foundation Chair in the department of Diabetes and Cancer Metabolism. His research focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress.

Here we talk about what is metabolism?, NAD system, factors affecting NAD system, ageing, anti-ageing research and how NAD system can be used in health?

About the guest

  • 00:00:00 Introduction

  • 00:00:51 What is metabolism?

  • 00:01:40 Metabolism at cellular level

  • 00:02:44 Different metabolic processes

  • 00:04:50 NAD (Nicotinamide adenine diamide) system

  • 00:08:20 Food to NAD system

  • 00:13:09 Evolutionary history of NAD system

  • 00:15:44 Molecular description of NAD system

  • 00:20:51 Synthesis of NAD

  • 00:23:21 What is metabolic stress?

  • 00:28:23 Consequences of metabolic stress on NAD system

  • 00:29:45 Conditions caused by NAD deficiency

  • 00:34:23 Impact of food on metabolic stress

  • 00:35:51 Different types of foods and NAD levels

  • 00:40:01 NAD levels and circadian rythem

  • 00:40:50 Genetic predisposition to NAD levels

  • 00:42:40 Are there population wide changes in NAD systems?

  • 00:47:25 Importance of NAD levels in the blood and how much of these can enter in the cell?

  • 00:50:08 Are there modified NMN compounds which can enter in the cell?

  • 00:52:01 NAD system and aging

  • 01:02:25 Objection against 'Sirtuins as drivers of aging'

  • 01:04:29 How do we understand aging?

  • 01:08:25 Biochemical explanation of aging

  • 01:12:20 What kind of biomarkers can help is in studying aging?

  • 01:15:33 Charles' work on NAD system

  • 01:17:05 What sort of system can help us study aging?

  • 01:23:37 Lifestyle and NAD system

  • 01:26:07 NR (Nicotinamide Ribose) as supplements

  • 01:27:19 Thank you!

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